• br Antibiotic drug discovery approaches Traditionally novel

  2024-10-01

  

  Antibiotic drug discovery approaches Traditionally, novel lipoxygenase were largely discovered by phenotypic screening approaches of various sources of compounds, such as natural products isolated from extracts of soil microbes and semi-synthetic or fully synthetic compound libraries derived from

• The specific mechanisms underlying glutamine dependency are

  2024-10-01

  

  The specific mechanisms underlying glutamine dependency are still being explored, and current research indicates that the mechanisms likely vary between breast cancer subtypes. In HER2-positive breast cancer, increased levels of the transcriptional activator PGC-1α lead to expression of genes that m

• br Acknowledgements br Introduction Diabetic

  2024-10-01

  

  Acknowledgements Introduction Diabetic complications are responsible for increased morbidity and mortality of diabetic patients. Increased flow of Reutericyclin through the polyol pathway under conditions of hyperglycemia contributes to the development of diabetic complications. Aldose reduct

• br Adiponectin in prostate cancer PC was documented as

  2024-09-30

  

  Adiponectin in prostate cancer PC was documented as the leading type of malignancy in males in the US with respect to both the estimated number of cases (22,800) and deaths (27,540) (Siegel et al., 2016). Studies have reported an association between low APN levels and the progression of PC (Micha

• In another study authors found that ADORA

  2024-09-30

  

  In another study, authors found that ADORA1 were present on the intrinsically photosensitive retinal ganglion h2 receptor antagonist (ipRGCs), and application of adenosine to rat retinas reduced light-evoked spiking of ipRGCs through suppression of a cAMP-mediated pathway (Sodhi and Hartwick, 2014).

• The major strength of this study is the

  2024-09-30

  

  The major strength of this study is the large sample size which increases the statistical power to detect the likely subtle differences in peripheral methylation observed in psychiatric disorders (Olsson et al., 2010). Larger studies help provide more robust estimates of true associations, as small

• The exact etiology of BPH is not completely understood

  2024-09-30

  

  The exact etiology of BPH is not completely understood, however this pathology has been associated with elevated diacylglycerol kinase levels of the androgen DHT (10). Thus, a valuable strategy in BHP treatment is the reduction of DHT (10) levels, by inhibiting its biosynthetic production [6], [8].

• br Autophagy in cancer br Phytochemicals as a valuable

  2024-09-30

  

  Autophagy in cancer Phytochemicals as a valuable source of autophagy modulation agents Epidemiological studies demonstrated that there is a strong association between diet and human cancer mortality so that daily consumption of phytochemicals declines the incidence of different types of cancer

• madecassol receptor In PMCA Mg favors the conversion E

  2024-09-30

  

  In PMCA, Mg2+ favors the conversion E1P → E2P [13] and, as in SERCA [11], it accelerates the phosphorylation displacing the E1–E2 equilibrium towards E1. In SERCA, Sørensen et al. [41], proposed that ATP reacts by an associative mechanism mediated by two Mg2+ ions to form an aspartyl-phosphorylated

• AG-1024 synthesis br HIF Blockade in AA Therapy In lieu

  2024-09-29

  

  HIF-α Blockade in AA Therapy In lieu of the evidence supporting a central role for HIF-α signaling in tumor angiogenesis and CC pathobiology, significant efforts have focused on the discovery of small-molecule HIF-α inhibitors (for exhaustive compendia, see [28,44,45]). In brief, inhibitors vary

• br Conclusions br Transparency document

  2024-09-29

  

  Conclusions Transparency document Acknowledgements This work was supported by a grant from the European Commission FP6 “Neuroprion” – Network of Excellence and Royal Veterinary College Bioveterinary science research project funding. We thank Professor Alun Williams (Cambridge University) fo

• Amyloid fibrils are insoluble high molecular

  2024-09-29

  

  Amyloid fibrils are insoluble, high-molecular-weight, non-crystalline aggregates and traditional experimental techniques for structure determination such as X-ray and solution NMR cannot resolve their high resolution structures [64], [68]. However, amyloid fibrils exhibit various advantageous featur

• This study demonstrates numerical alterations of creatinine

  2024-09-29

  

  This study demonstrates numerical alterations of creatinine levels potentially reflecting ongoing or even higher myocardial contraction of the LAA after successful LAAC. Creatinine is the direct breakdown product of creatine in muscle, the key metabolite for energy supply during muscular and myocard

• The proposed formulation is however

  2024-09-29

  

  The proposed formulation is, however, challenging to solve since the structured sparsity-inducing norms are non-smooth. In order to solve the new objective function, we consider two different approaches: proximal averaging, which takes the average the solutions from the proximal operator for the ind

• br Conflicts of interest br Acknowledgements This

  2024-09-29

  

  Conflicts of interest Acknowledgements This work was sponsored by grants from Longyan University Scientific Research Fund for the Young Scholars (LQ2016010), Middle-aged and Young Teachers Education Research Projects of Fujian Province (JAT170569), Longyan University Scientific Research Fund f

15105 records 42/1007 page Previous Next First page 上5页 4142434445 下5页 Last page