• LDC000067 Gap junction intercellular communication GJIC

  2022-03-12

  

  Gap junction intercellular communication (GJIC) facilitates the exchange of ions, metabolites, Ca2+, inositol phosphates, and/or cyclic nucleotides of up to 1.8 kD in size between LDC000067 through contact-dependent mechanisms [3,4]. Oocyte growth and development (as depicted in Fig. 1) depends, at

• More recently Dal Peraro and coworkers carried out s CG

  2022-03-12

  

  More recently, Dal Peraro and coworkers [38] carried out 4 μs CG MD simulations of GS with six randomly placed C9915-55 peptides embedded into a synaptic plasma bilayer model. This lipid raft model was constituted by 32 different aspirin solubility and cholesterol (54.74%). In this study, the autho

• Contrary to the transient nature of signal transmission thro

  2022-03-12

  

  Contrary to the transient nature of signal transmission through PLCβ, genome-wide RNAi screens revealed that the signaling events driven by Gαq that result in aberrant cell proliferation depends on highly specific protein-protein interactions, rather than solely on diffusible second messenger system

• The primary cancer lesion was mostly in

  2022-03-12

  

  The primary cancer lesion was mostly in the uterus and adnexa, followed by the gastrointestinal tract, brain, blood, and kidney and Stiripentol mg (Fig. 2A). Histopathological findings indicated that most cancers were adenocarcinomas, followed by squamous cell carcinomas, glioblastomas, malignant l

• A biochemical characterisation of this functionally crucial

  2022-03-11

  

  A biochemical characterisation of this functionally crucial LSD1-p53 interaction is the focus of this study. Using several complementary assays [29], [30], [31], [32], we find that a well-defined segment of p53-CTD is capable of binding to LSD1 active site, thereby inhibiting the enzymatic activity

• Treatment with histamine had no effect on

  2022-03-11

  

  Treatment with histamine had no effect on histamine H1 receptor expression in HepG2 D8-MMAE (Fig. 1), while knockdown of histamine H1 receptor expression prevented histamine from repressing apo A-I gene expression (Fig. 2). Overexpression of the histamine H1 receptor regulated apo A-I promoter acti

• Histamine in the central nervous system is produced mainly

  2022-03-11

  

  Histamine in the central nervous system is produced mainly in the tuberomammillary nucleus and is implicated in learning and memory as well as sleep and wakefulness, feeding and drinking, and neuroendocrine regulation . For instance, treatment with antihistamines not only produces drowsiness but als

• 2-D08 receptor GPR shares a amino acid sequence identity in

  2022-03-11

  

  GPR81 shares a 52% amino 2-D08 receptor sequence identity in humans to GPR109A [1], [2], [3]. In addition, GPR81 is localized more specifically to the adipose tissue [3]. In 2008, lactate was discovered to be the endogenous ligand for GPR81 [9], [10]. Plasma lactate levels reach concentrations capa

• In this study we further expanded

  2022-03-11

  

  In this study, we further expanded the antitumor bioactivity, with the BALB/c S-180 tumor model, which is long-established due to its highly aggressive in all strains of laboratory mice and rats (Cui et al., 2003). We investigated the tumor-regressing ability of β-glucan by different modes of admini

• To investigate if such an effect is

  2022-03-11

  

  To investigate if such an effect is observed in native GlyT1, we introduced S605D and S605A mutations into GlyT1 and transfected these DNA constructs into N2a cells. For an internal control of calpain cleavage, we also introduced the first 100 amino-acids of the rat GlyT2N terminus upstream of the m

• br Materials and Methods br Results All of the studied

  2022-03-11

  

  Materials and Methods Results All of the studied transporter genes were expressed at detectable levels in all the analyzed samples at mRNA level by means of applied rt-PCR method (CTteniposide was observed for ABCC4, ABCC1, ABCG2, SLC22A3, and SLC22A18 (less than 10% of mean expression for the

• After brain injury adenosine levels rapidly

  2022-03-11

  

  After brain injury, adenosine levels rapidly increase in the brain [9,10]. As shown in our previous studies, the increased adenosine concentration acts on adenosine A2A receptors (A2ARs), increasing post-traumatic glutamate levels in the brain and exacerbating the severity of injuries [11,12]. Accor

• In conclusion we have designed

  2022-03-11

  

  In conclusion, we have designed and characterized a novel series of EAAT-blockers, exemplified by (-[4-(2-bromo-4,5-difluorophenoxy)phenyl]--asparagine)—a potent, selective, competitive non-substrate inhibitor of EAAT-2. As one of the most potent and selective EAAT-2 inhibitors identified to date,

• br Vesicular glutamate transporters VGLUTs br Conclusions Du

  2022-03-11

  

  Vesicular glutamate transporters (VGLUTs) Conclusions Due to the molecular cloning of EAAT and VGLUT subtypes, a better understanding of the functional properties of these carriers has been elucidated over the last few years. In the case of the EAATs, specific blockers, such as trans-2,4-PDC,

• Numerical models of blood regulation

  2022-03-10

  

  Numerical models of blood regulation provide insight into the interaction of the cellular-level and macro-scale phenomena studied in silico, a term referring to computer simulations of the dynamics of complex biological systems as opposed to in vivo or in vitro experimental studies. These in silico

15267 records 441/1018 page Previous Next First page 上5页 441442443444445 下5页 Last page