• Further our data demonstrate a role for mitochondrial AIF

  2022-01-17

  

  Further, our data demonstrate a role for mitochondrial AIF in oxidative cell death induced by RSL3. We found that AIF knockdown using siRNA completely protected the Desfuroylceftiofur against RSL3 induced oxidative stress. Similar to other pathways of caspase-independent programmed cell death, mitoc

• aspartame products australia br Problem of cellular retentio

  2022-01-15

  

  Problem of cellular retention not only affects the cellular activity of the nanoparticles and nanocomplexes but can also have ramifications in their in vivo applications. While inorganic nanoparticles are being developed extensively for detection as well as treatment of different human diseases, i

• The molecular mechanisms underlying VSMC

  2022-01-15

  

  The molecular mechanisms underlying VSMC ETB receptor upregulation have been studied after 24–48h organ culture in both coronary and cerebral arteries. The increased expression of contractile ETB receptor at these time points has been shown to depend on transcriptional mechanisms and PKC and the ext

• br Hedgehog pathway The Hedgehog pathway Fig derives

  2022-01-15

  

  Hedgehog pathway The Hedgehog pathway (Fig. 1) derives its name from Hh gene mutant Drosophila, which presents a spiked phenotype resembling the animal “hedgehog” [13]. The Hh proteins control embryonic development in vertebrates, where the signaling mechanisms mediated by the proteins are multip

• Aspartame l aspartyl l phenylalanine methylester is a dipept

  2022-01-15

  

  Aspartame (l-aspartyl l-phenylalanine methylester) is a dipeptide artificial sweetener that is widely used as a non-nutritive sweetener in various food products [1]. The increased market of dietary products and the development of new synthetic sweetening compounds have not been sufficiently explored

• Although it has been observed in

  2022-01-15

  

  Although it has been observed in numerous studies and by many investigators that intraplatelet cGMP elevation results in platelet inhibition, there are a few papers which proposed a platelet stimulatory role for cGMP when elevated in response to NO donors or PDE5 inhibitors in mouse and human platel

• br Discussion The pattern of activity exhibited by SSR

  2022-01-15

  

  Discussion The pattern of activity exhibited by SSR 504734 and Lu AA21279 in the MEST test was very similar. Both compounds were inactive at the lowest dose (3.0mg/kg), but exhibited robust increases (∼150%) at 10mg/kg followed by a maximal detectable response at 30mg/kg. Based on the magnitude o

• With these cyclopropene glutamate derivatives in hand

  2022-01-15

  

  With these cyclopropene-glutamate derivatives in hand, we tested their ability to ligate with popular bioorthogonal reagents (Fig 3). First, we tested their ability to ligate with a tetrazine (3,6-Di-2-pyridyl-1,2,4,5-tetrazine) via an inverse electron demand Diels-Alder reaction by monitoring the c

• Analysis of the i motif structures during

  2022-01-15

  

  Analysis of the i-motif structures during biased unfolding of G-quadruplexes leads to the conclusion that at acidic pH the i-motif is absolutely unaffected by that process. The hydrogen bonds within the i-motif are intact (Fig. 3D) and they only fluctuate around mean values. On the other hand, the i

• br Materials and methods br Acknowledgments We are grateful

  2022-01-14

  

  Materials and methods Acknowledgments We are grateful for financial support from the National Natural Science Foundation of China (Grants No. 81661148046 and 81773762, China) and the “Personalized Medicines—Molecular Signature-based Drug Discovery and Development”, Strategic Priority Research

• br Introduction Stroke is the second cause

  2022-01-14

  

  Introduction Stroke is the second cause of death worldwide and the first cause of acquired motor disability in adults [1], [2]. In sub-Saharan Africa, stroke is the first cause of admission in neurology departments [3]. In Cameroon, the in-hospital mortality of stroke is estimated at 26.8% [4]. A

• br Materials and methods br

  2022-01-14

  

  Materials and methods Results Discussion It has previously been reported that EZH2 plays a key role in the silencing of tumour suppressor genes through methylation of H3K27me3 in the promoter region of these genes in neuroblastoma [32], [40]. In this study, we show that EZH2 is aberrantly g

• br Materials and methods br Results br Discussion It was

  2022-01-14

  

  Materials and methods Results Discussion It was previously shown that heterologous DNA vaccines composed of fused cDNA fragments encoding chimeric NH2-terminal human HER2 and COOH-terminal rat neu sequences stimulated stronger antibody responses and protective antitumor immunity than either

• Aspartame l aspartyl l phenylalanine methylester is a dipept

  2022-01-14

  

  Aspartame (l-aspartyl l-phenylalanine methylester) is a dipeptide artificial sweetener that is widely used as a non-nutritive sweetener in various food products [1]. The increased market of dietary products and the development of new synthetic sweetening compounds have not been sufficiently explored

• In contrast the sGC activator

  2022-01-14

  

  In contrast, the sGC activator BAY 58-2667 relaxed the CC in a concentration-dependent manner (Figure 4B), a response that was significantly increased in the CC of sGCβ1ki/ki mice compared with WT mice. The finding that BAY 58-2667 also possessed a corporal relaxing effect in WT mice is suggestive b

15270 records 472/1018 page Previous Next First page 上5页 471472473474475 下5页 Last page